In the field of design, Diego Chilo has collaborated with numerous companies including Andromeda, Arcom, Arflex, Altek, Disegnoluce, Leucos, Light4, Mareco Marino Cristal, Onoluce, Panzeri, Prandina, Sirrah, Venini, and Zaneen. In 1985 he began a course of study and collaboration with the architect Fiorenzo Valbonesi.
From 2003 to 2006, Chilo was in charge of artistic direction of Ono-Light. From 2006 to 2008 he worked with the Faculty of Industrial Design in Florence. He is currently a member of the Scientific Committee of Art and Steel Architecture.